Systematic benchmarking of single-cell ATAC-sequencing protocols
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Application
Semi-Permeable Capsules for Single-Cell Assay Innovation
Discover
Semi-Permeable Capsules (SPCs) are versatile microreactors that isolate cells and maintain their compartmentalization during bulk reactions. Their robustness and permeability enable seamless single-cell assay customization through simple buffer exchanges.
BULK–LIKE MULTI–STEP PROCESSING
In contrast to droplet-based systems, SPCs allow incompatible reactions (e.g. lysis and amplification) to be decoupled by removing previous reaction components through simple washing, ensuring each reaction occurs under optimal conditions.
This flexibility empowers a mix-and-match approach to profile the single-cell genome, transcriptome, epigenome, and beyond.
1. Prepare
2. Process
3. Finalize
White paper: The overview of the Semi-Permeable Capsule (SPC) technology
Download PDFPublications featuring Single Cell Assay Innovation
High throughput Single Cell Metagenomic Sequencing with Semi-Permeable Capsule: Unraveling Microbial Diversity at the Single-Cell Level in Sewage and Feces Microbiomes
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Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads
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inDrops-2: a flexible, versatile and cost-efficient droplet microfluidic approach for high-throughput scRNA-seq of fresh and preserved clinical samples
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SPCs are compatible with standard FACS instrumentation, enabling the enrichment of fluorescent populations of interest. Capsules can also be sealed by reemulsifying them in oil, preventing small molecule leakage and enabling seamless sorting on the Styx platform.
EXCITED TO ENABLE
Sequencing
Single-cell DNA-seq
Targeted sequencing
Single-cell multiomic sequencing
Immune profiling
Single-cell accessible chromatin profiling
MICROBIOLOGY
Antimicrobial resistance surveillance
Cultivation of anaerobic microorganisms
Extremophiles research
Viral genomics
OTHER
Spheroid formation
Nucleic acid cytometry
Co-culturing
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