Single-cell DNA & RNA Co-sequencing
Jointly profile DNA and RNA from the same cell to directly connect genotype and phenotype
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Technology
Semi-Permeable Capsules
Discover
Imagine running bulk reactions as you are used to, yet seamlessly achieving single-cell resolution. Semi-Permeable Capsules (SPCs) make this dreamlike idea into reality, enabling the investigation of various modalities of thousands-to-millions of single cells all at once.
Semi-Permeable Capsules have an aqueous core and sieve-like walls that keep the cells and nucleic acids partitioned inside, while allowing the free flow of the surrounding solution, be it molecular biology reagents, buffers or media.
This unique feature allows multi-step processing of all cells in a single tube by sequentially adding and removing the desired reaction mixtures with nothing more than the pipet, all while keeping cells separated in their individual capsules.
The distinct non-droplet nature of SPCs also enables sequential processing of incompatible reactions (e.g. harsh cell lysis and nucleic acid amplification), ensuring each reaction takes place under optimal conditions.
Features
EASY MULTI–STEP PROCESSING
Perform reactions on single-cells with standard lab equipment
Optimal Conditions
Run every molecular biology reaction under optimal conditions
Massive Parallelization
Analyze thousands-to-millions of single-cells in parallel in a single tube
Versatile & Flexible
Compatible with diverse cell types and biochemical reactions
Seamless Cell Culture
Unlimited nutrient availability for optimal cell growth
Gentle Release
Release intact nucleic acids or live cells under biocompatible conditions
SPCs ENABLE NOVEL APPLICATIONS
Single-Cell Microbial Genomics
Characterize complex microbiomes with strain-level resolution to uncover microbial dark matter and trace HGT
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Single-Cell Assay Innovation
Utilize semi-permeable capsule technology to develop your own custom single-cell multi-step workflows
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Single-Cell Cultivation
Scale up the cultivation of spheroids or isolated microbial strains for high-throughput experiments
Read moreSPC GENERATION
SPCs are formed by controllably mixing two immiscible polymers in a microfluidic chip and inducing crosslinking, to create a size-selective hydrogel shell surrounding the aqueous core. This process has been streamlined for the ease of use, requiring just the press of a button.
Flux is a specialized SPC generation device with a user‑friendly, single–button operation.
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